The effect of ibuprofen on aging and cognitive function

 
   Lead Investigator:    Chia-Chen Liu
   Institution      :    Mayo Clinic
   E-Mail           :    liu.chiachen@mayo.edu
   Proposal ID      :    661



   Proposal Description:
   Aging is accompanied by increased neuroinflammation, synaptic dysfunction and ?? cognitive deficits both in rodents and humans. Previous studies suggest that non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, have been associated with a reduction in the incidence of AD, and increased longevity in simple organisms. We are interested in examining how treatment of NSAID (in particularly ibuprofen) affects amyloid pathology, brain activity and cognitive functions, and whether these effects are age-dependent.?? For the MRI data, I am interested in examining whether there is brain atrophy (ie, hippocampus volume) and/or microbleed that are associated with ibuprofen treatment in cognitive function, and whether age and APOE genotype plays a role. ??I hope to get MRI data to examine how age and APOE genotype associate with different regions of brain atrophy and microbleed, which might contribute to cerebral amyloid angiopathy (CAA)/AD.